药物所十分注重原始创新，不断加强基础研究和应用基础研究。至2020年底，共发表论文9700余篇，其中SCI论文4113篇；第一作者单位发表论文7251篇，其中SCI论文2852篇。发表论文影响力不断提升，近年来在Cell、Lancet、Nature Chemistry、Nature Chemical Biology、Cancer cell、Journal of American Chemical Society、Angewandte Chemie International Edition、Nature Communications等国际知名期刊上发表了高水平论文。
作者：Wei Qian; Bai Jian; Yan Daojiang; Bao Xiuqi; Li Wenting; Liu Bingyu; Zhang Dan; Qi Xiangbing; Yu Dequan; Hu Youcai
来源：Acta Pharmaceutica Sinica B
摘要： Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene
作者：Chen Yuanyuan[1]; Li Zhaojun[1]; Chen Xiaoguang[1]; Zhang Sen[
来源：Acta Pharmaceutica Sinica B
摘要： Enormous studies have corroborated that long non-coding RNAs (lncRNAs) extensively participate in crucial physiological processes such as metabolism and immunity,
作者：Liu Hui[1]; Wu Yuzhuo[1]; Guo Qinglan[1]; Shao Shuai[1]; Xu Chengbo[1]; Zhang Tiantai[1]; Shi Jiangong[1]
来源：Chinese Chemical Letters
摘要： Two sulfonated seco C_(20)-diterpenoid alkaloids, aconapelsulfonines A(1)and B(2), were isolated from an aqueous extract of the raw material of “Fu Zi”(the Aconitum carmichaelii lateral roots),
作者：Zheng, Xiang-jin[1];Li, Wan[1];Yi, Jie[2];Liu, Jin-yi[1];Ren, Li-wen[1];Zhu, Xiao-ming[3];Liu, Shi-wei[4];Wang, Jin-hua[1];Du, Guan-hua[1]
来源：ACTA PHARMACOLOGICA SINICA
摘要： Triple-negative breast cancer (TNBC) is characterized by low expression of human epidermal growth factor receptor-2 (HER2), estrogen receptor (ER), and progesterone receptor (PR),
作者：Pengxu Wang[1];Sarah M. Batt[2];Bin Wang[3];Lei Fu[3];Rongfei Qin[1];Yu Lu[3];Gang Li[1];Gurdyal S. Besra[2];Haihong Huang[1]
来源：Journal of Medicinal Chemistry
摘要： In this study, we report the design and synthesis of a series of novel thiophene-arylamide compounds derived from the noncovalent decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1) inhibitor TCA1 through a structure-based scaffold hopping strategy.
